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TPX 0005 inhibits H2228 cell migration in a wound healing assay with similar activity to saracatinib TPX 0005 is able to not only inhibit the wild type and a broad spectrum of mutant ALKs but also overcome primary resistance and suppress metastatic features by inhibiting SRC Assay.
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TPX File Summary Most TPX files can be viewed with two known software applications typically Topo North America developed by Interscape It's main file type association is the DeLorme Topo Project File format but also includes one other rarely seen file types Although TPX files are traditionally categorized as GIS Files they can also be Developer Files.
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Repotrectinib (TPX 0005) Is a Next Generation ROS1 TRK ALK.
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Solvent front substitutions such as ALKG1202R ROS1G2032R or ROS1D2033N TRKAG595R and TRKCG623R are among the most recalcitrant of these mechanisms Repotrectinib (TPX 0005) is a rationally designed low molecular weight macrocyclic TKI that is selective and highly potent against ROS1 TRKA C and ALK!
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