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Download 9reat stand by me em karaokeQuantitative Microsphere System (QMS) technology and was implemented on an automated analyser (Abbott Architect ci4100).
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Pharmacodynamics and Therapeutics, Institute of Translational Medicine, University of Liverpool, Liverpool, UK2Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
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PD index in a variety of infection models and in patients.
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Download 9reat stand by me em karaokeIn vivo PK studies.
In vitro PK and PD studies.
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The strain was oxacillin resistant by Etest (Oxoid).
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These updated targets are based on small retrospective studies in adults.
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Download 9reat stand by me em karaokeTeicoplanin is a glycopeptide with a similar spectrum of antibacterial activity to vancomycin.
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Download 9reat stand by me em karaokeJournal of Antimicrobial Chemotherapy.
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In the right column the effect on the resistant bacterial populations is shown.
The mean value of the bacterial burden from the left and right thighs from each mouse was determined.
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Three mice were used per dose timepoint.
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About the Journal of Antimicrobial Chemotherapy.
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We considered both the antibacterial effect of teicoplanin and the emergence of resistance to teicoplanin as primary study endpoints.
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PD information that provides a rationale for the optimal use of this agent.
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For the paediatric simulations, we used the population PK estimates and covariance matrix from a previously developed PK model in children.
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Download 9reat stand by me em karaokeApplied Pharmacokinetics and Bioinformatics, The Saban Research Institute and The Division of Paediatric Infectious Diseases, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA, USA.
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PD indices that best describe the killing of susceptible subpopulations and suppress emergence of resistance.
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Pharmacodynamics of teicoplanin against MRSA.
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Sampling occurred during the first dose interval and at day 6 of therapy.
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PD index was then further explored with the in vivo mouse data.
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Monte Carlo simulations from previously developed population PK models in adults and children were conducted to explore the probability of target attainment (PTA) for teicoplanin dosage regimens against the current EUCAST WT susceptibility range.
PD of teicoplanin against MRSA.
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Fractional target attainment was calculated for the various regimens.
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The coefficient of determination and visual examination of the fit were used to discriminate the various PD indices.
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Download 9reat stand by me em karaokeEach experiment comprised a control arm and three cohorts of mice receiving teicoplanin.
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For the adult simulations we used the population PK estimates and covariance matrix from a previously developed population PK model in adults.
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The mean and SD for a group of three mice was then calculated.
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Monte Carlo simulations and probability of target attainment (PTA) analysis.
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Download 9reat stand by me em karaokeThe MIC for the strain was determined using the EUCAST broth microdilution methodology on three separate occasions.
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Cmin at steady state (between days 3 and 4 of treatment) was performed for each dosage regimen for both adults and children.
These simulated patients were used to examine the outcomes of candidate regimens of teicoplanin.
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