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Download 9reat stand by me em karaokeSampling occurred during the first dose interval and at day 6 of therapy.
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Fractional target attainment was calculated for the various regimens.
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Journal of Antimicrobial Chemotherapy.
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We considered both the antibacterial effect of teicoplanin and the emergence of resistance to teicoplanin as primary study endpoints.
The MIC for the strain was determined using the EUCAST broth microdilution methodology on three separate occasions.
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Download 9reat stand by me em karaokeDrug exposure targets that are associated with a high probability of a successful clinical outcome are relatively poorly defined.
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The strain was oxacillin resistant by Etest (Oxoid).
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Download 9reat stand by me em karaokeTeicoplanin is a glycopeptide with a similar spectrum of antibacterial activity to vancomycin.
The rate of growth is a balance between bacterial growth and death.
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Pharmacodynamics and Therapeutics, Institute of Translational Medicine, University of Liverpool, Liverpool, UK2Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
PD of teicoplanin to that provided by the HFIM.
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We finally bridged the experimental results to patients to reflect on the adequacy of current EUCAST in vitro susceptibility breakpoints.
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PD index in a variety of infection models and in patients.
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For the paediatric simulations, we used the population PK estimates and covariance matrix from a previously developed PK model in children.
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Monte Carlo simulations and probability of target attainment (PTA) analysis.
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We considered this relevant to evaluate the impact of frequency on AUC and Cmin attained drug exposures.
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Monte Carlo simulations were performed with Pmetrics.
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The coefficient of determination and visual examination of the fit were used to discriminate the various PD indices.
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Download 9reat stand by me em karaokeIn vitro susceptibility and mutational frequency.
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Monte Carlo simulations from previously developed population PK models in adults and children were conducted to explore the probability of target attainment (PTA) for teicoplanin dosage regimens against the current EUCAST WT susceptibility range.
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PD indices that best describe the killing of susceptible subpopulations and suppress emergence of resistance.
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Download 9reat stand by me em karaokePharmacodynamics and Therapeutics, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
These simulated patients were used to examine the outcomes of candidate regimens of teicoplanin.
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Cmin at steady state (between days 3 and 4 of treatment) was performed for each dosage regimen for both adults and children.
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For the adult simulations we used the population PK estimates and covariance matrix from a previously developed population PK model in adults.
Each experiment comprised a control arm and three cohorts of mice receiving teicoplanin.
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